In silico assessment of histotripsy-induced changes in catheter-directed thrombolytic delivery
Introduction: For venous thrombosis patients, catheter-directed thrombolytic therapy is the standard-of-care to recanalize the occluded vessel.Limitations with thrombolytic drugs make the development of adjuvant treatments an active area of research.One potential adjuvant is histotripsy, a focused ultrasound therapy that lyses red blood cells withi